Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism.

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Accelerated breakdown of immunoglobulin G (IgG) in myotonic dystrophy: a hereditary error of immunoglobulin catabolism.

Myotonic dystrophy is a hereditary progressive muscular abnormality with dominant transmittance that was first proposed as a separate entity by Batten and Gibb (1) and by Steinert (2) in 1909. The muscular abnormality that is the dominant feature of the disease is characterized by weakness, wasting, and myotonia, especially of the facial, neck, and distal musculature. Other abnormalities freque...

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X-linked agamaglobulinemia (XLA) or Bruton’s disease is a genetic disease resulting from a mutation in the Bruton’s tyrosine kinase (Btk) gene. This mutation leads to B cell arrest during differentiation (1). This disease was first described by Ogden Bruton in 1952 (2). Approximately 85% of the affected subjects are male (3). This disorder is inherited as an X-linked recessive trait. Carrier fe...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1966

ISSN: 0021-9738

DOI: 10.1172/jci105346